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22,149,150 TSC1 acts as a regulator of the stability of TSC2, preventing the degradation of TSC2, while TSC2 is a GTPase activating protein (GAP) that inactivates Rheb, a GTPase of the Ras family, and other small G proteins

BB10 peptide remains a research compound and should be treated as such

Patients with conditions showing strong preclinical evidence and limited alternative treatment options may represent reasonable candidates following thorough informed consent discussions

AOD-9604 is the most studied version: a Phase 2b obesity trial reported it was well tolerated with a safety profile comparable to placebo and no rebound weight gain, and it doesnt alter IGF-1 or glucose (BioSpace)